Poison-induced cardiogenic shock (PICS) as a result of beta-blocker (�Ÿ-blocker) or calcium channel blocker (CCB)\noverdose is a common and potentially life-threatening condition. Conventional therapies, including fluid resuscitation,\natropine, cardiac pacing, calcium, glucagon, and vasopressors often fail to improve hemodynamic status. High-dose\ninsulin (HDI) is an emerging therapeutic modality for PICS. In this article, we discuss the existing literature and highlight\nthe therapeutic success and potential of HDI. Based on the current literature, which is limited primarily to case\nseries and animal models, the authors conclude that HDI can be effective in restoring hemodynamic stability, and\nrecommend considering its use in patients with PICS that is not responsive to traditional therapies. Future studies\nshould be undertaken to determine the optimal dose and duration of therapy for HDI in PICS.
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